In the production of traditional embryonic vaccines, all manual operations are used, resulting in low production efficiency, high labor intensity, and difficulty in ensuring product quality uniformity. This production process is not conducive to modern management, especially in today's rapidly developing science and technology. The era calls for reform and innovation, changing the existing production situation and achieving automation in the production process.
In the production of inactivated embryonic vaccines, the use of automated equipment has completely changed the traditional production process, making the process simple, reducing the footprint, increasing production capacity by four times under the same production area, saving air conditioning energy, and eliminating the need to set up a hundred level zone in the production area. Due to the connection of devices to different production areas, automatic transfer of chicken embryos from one area to another saves a lot of manpower. Due to the fact that the processing of chicken embryos is entirely carried out by equipment, pollution is reduced, product quality is improved, and uniformity of product quality is achieved.
The eggs undergo a pre-treatment process and enter the pre incubator, where they hatch for about 10 days. After hatching, the chicken embryos were inspected and found to be unqualified. They were then transported to the pre inoculation room via a conveyor belt.
The chicken embryos are disinfected and inoculated by an automatic inoculation machine, then enter the inoculation room and are sent to the incubation room for 3 days of incubation. After hatching, the eggs are sent for inspection. If any unqualified chicken embryos are detected, they are sent to the cold storage for frozen eggs. The frozen chicken embryos are fed into an automatic harvester for harvesting. The urine bladder fluid is collected in a collection tank and waiting for quality inspection. Qualified bladder fluid enters the inactivation tank through the material tube.
Equipment features:
No | Features | Description |
1 | Automation of the entire vaccination process | Highly intelligent, capable of automatically completing processes such as egg disinfection, sterile air drying, punching, poisoning, injection needle disinfection, etc. All processes are controlled by a programmable controller. Due to the small pinhole, chicken embryos do not need to be sealed. This device can process 20000 chicken embryos per hour. |
2 | Automation of the entire harvesting process | The process is automatic harvesting, and the job of humans is to deliver eggs to the equipment and place the waste embryos after harvesting. After the collection bottle is filled, the equipment automatically stops, and the quick connector on the collection head allows the operator to quickly replace the new collection bottle. The entire process is simple to operate and efficient. This device processes 16000 chicken embryos per hour. |
3 | Process sterile environment | The entire process is carried out under a hundred level laminar flow hood to ensure that the collection of urinary bladder fluid is a sterile operation. And there is no need for human intervention, greatly reducing the probability of pollution. |
4 | Save manpower | Only 4 people are needed to complete the equipment operation. Compared to traditional manual labor, the labor intensity is greatly reduced. Usually, it can complete work tasks for around 20 people. |
5 | Easy to operate | The needle can be installed and disassembled as a whole, and placed in a stainless steel box for disinfection and sterilization. After the venom bottle is securely placed in the rack, the inoculation operation can be carried out. After completing the work, clean it in place with prepared sterile water. During operation, the device can detect the injection amount at any time to ensure the accuracy of the injection work. When there is a fluctuation in air pressure, the equipment automatically gives an alarm and takes necessary protective measures. The suction head, along with the hose and connector, is installed and disassembled as a whole and placed in a stainless steel box for disinfection and sterilization. Easy installation, quick connector can quickly replace the collection tank. The machine uses a touch screen as the control platform and is easy to operate. After the collection bottle is filled with liquid, the machine automatically stops. After harvesting, the pipeline can be cleaned in place. Assemble the harvesting components as a whole, place them in a special box, and disinfect and sterilize them. |
6 | Localization of all accessories | All components used in the machine are domestically produced. Vulnerable parts such as cylinders, air pipes, motors, bearings, etc. can be purchased in the market for easy maintenance and repair in the future. |
7 | Consumption | The maximum power consumption is around 5000W. Use oil-free and waterless 0.4MPa compressed air. |
8 | Compliant with GMP requirements | The body is entirely made of 304 stainless steel components, with key components made of 316L stainless steel material. The equipment has a smooth appearance and no dirt spots. Easy to maintain and repair. Efficient filters are used to supply air in the workspace, with a wind speed greater than 0.25 meters per second. |
9 | Embryo virus vaccine production line operation | By combining the use of chicken embryo inspection machines, automatic inoculation machines, and waste embryo processing machines, the production line operation of embryotoxic vaccines can be realized. The entire production process is automated, with a small battlefield area, saving operators, improving product quality, and reducing pollution losses. |
Basic structure and working principle
The fully automatic embryo harvester consists of an egg feeding device, egg disinfection device, embryo drying device, inoculation device, needle disinfection, harvesting device, and harvesting tank. The electrical control of each component is composed of programmable controllers and electrical actuators
The egg feeding device consists of an egg tray determination button and an egg tray pushing cylinder. After pressing the egg tray confirmation button, the egg tray cylinder will automatically push the egg tray to the designated position.
2. The egg disinfection device consists of a disinfectant storage box, an air pressure tank, and an aerosol generation device. After the disinfectant flows from the disinfectant storage box into the aerosol generation device, when the egg tray is in place, the pressure tank releases air pressure to the aerosol generation device, generating disinfectant aerosol to disinfect the egg embryos.
3. The egg embryo drying device consists of a centrifugal fan. Blow dry the disinfectant on each embryo.
4. The inoculation device consists of an inoculation bracket cylinder, a perforated cylinder, an inoculation cylinder, and an injection cylinder. The inoculation bracket cylinder is controlled by the cylinder positioning screw rod to drill the height of the embryo hole. The punching cylinder controls the punching needle to complete the egg embryo punching. The injection cylinder controls the entry of the inoculation needle into the embryo. The injection cylinder controls the inoculation amount of egg embryos.
5. The needle disinfection device consists of a needle disinfection box. When the needle is disinfected, the inoculation bracket cylinder rises and the needle disinfection box enters the designated position to disinfect the needle.
6. The inoculation pressure equalization tube is connected to the inoculation bottle through a silicone tube, and the injection pressure is connected to the inoculation bottle through a filtering device.
7. The harvesting device consists of a harvesting head and a harvesting cylinder, with the harvesting cylinder controlling the height and position of the harvesting head for egg feeding.
8. The harvesting head is connected to the harvesting tank through a silicone tube, and a vacuum pump is connected to the harvesting tank. When the harvesting head enters the embryo, the bladder fluid is harvested into the harvesting tank through the vacuum pump.
Equipment details:
1. We has many years of experience in the production of tank fluid vaccines in the industry; Since 2000, we have been developing and designing chicken embryo inoculation machines; The first semi-automatic vaccination machine was manufactured in 2002; We manufactured a fully automatic inoculation machine in 2003 and developed and designed a chicken embryo harvesting machine in the same year. We have now produced the ninth generation of new inoculation and harvesting machines and have applied for national patents.
2. The equipment is widely applicable, and according to the customer's production volume, the size of the egg tray is 30 or 36 pieces, 42 pieces, 72 pieces, 150 pieces, designed with fully automated production lines.
3. Control system: Adopting fully automated PIC control
4. Air pressure spray disinfection: spray disinfection for each chicken embryo (unique patent)
5.Vaccination System: Pneumatic Vaccination to Ensure Vaccination Accuracy (Unique Patent)
6. Harvesting System: The company adopts an eccentric harvesting head design to ensure a harvesting rate of over 99%, effectively avoiding the harvesting of egg yolks (unique patent)
7. Egg lifting and shell cutting equipment (the company adopts German technology to ensure that more than 99% of chicken embryos are not damaged. Unique patent)
8. Harvester conveyor belt and transfer window (international exclusive product)
Contact: Support team
Phone: +86-13818385401
E-mail: support@pharmatec-gmp.com
Add: 6th Floor, No. 615, Ning Qiao Road, Shanghai, China